The b lymphocyte stim lator ( blys ) also known as baff , tall - 1 , thank , ztnf4 , is the most recent addition to the tumor necrosis factor family ( tnf ) ligands . blys induces both in vivo and in vitro b cell proliferation , differentiation and immunoglob lin secretion . meanwhile , it also strongly suppresses the growth of tumor cell lines . the over - production of blys is associated with the development of certain autoimmune disease , such as systemic lupus erythaematosus ( sle ) , rheumatoid arthritis , myasthenia gravis , sj greh ' s syndrome 人b淋巴细胞刺激因子( hblys )是1999年发现的肿瘤坏死因子超家族成员。最早发现其可诱导肿瘤细胞凋亡，之后发现它是一个强有力的b细胞共刺激因子，它在体外及转基因动物体内可明显刺激b细胞的生长，免疫球蛋白分泌，并导致动物自身免疫性改变。
