In the general public , gaucher disease affects approximately 1 in 100 , 000 persons 在通常情况下，戈谢病患者为1 / 100000 。
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Gaucher ( pronounced " go - shay " ) disease is an inherited illness caused by a gene mutation 戈谢病是一种由基因突变引起的疾病。
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According to the national gaucher foundation , 2500 americans suffer from gaucher disease 根据国际戈谢病组织统计， 2500美国人患有戈谢病。
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Gaucher disease can result in pain , fatigue , jaundice , bone damage , anemia , and even death 戈谢病会导致疼痛、疲劳、黄疸、骨髓的破坏、贫血甚至死亡。
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In people with gaucher disease , the body is not able to properly produce this enzyme , and the fat can not be broken down 在戈谢病患者体内，不能完全合成该酶，从而导致葡萄糖脑苷脂不能被降解。
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Among the ashkenazi jewish population , gaucher disease is the most common genetic disorder , with an incidence of approximately 1 in 450 persons 在德系犹太人中，戈谢病是最普遍的基因突变疾病，大约为1 / 450 。
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Enzyme replacement therapy can stop and often reverse the symptoms of gaucher disease , allowing patients to enjoy a better quality of life 酶替换疗法可以阻止和减缓戈谢病的病症，使病人能够更好地享受高质量的生活。
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Gaucher disease is considerably more common in the descendants of jewish people from eastern europe ( ashkenazi ) , although individuals from any ethnic group may be affected 戈谢病在东欧犹太人（德系犹太人）的后裔中相当普遍，虽然在相似民族中也存在类似个体。
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The finding that may cause most controversy , however , isthat in the asian groups there has been strong selection for one variant of agene that , in a different form , is responsible for gaucher ' s disease 然而，这些发现可能引起的最大的纷争就是在亚洲种群中由于戈谢病对一种基因的变异体，以另一种形式，存在着强选择。
